https://compcylab.squarespace.com/contact-1 daily 0.75 2021-02-10 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Contact https://compcylab.squarespace.com/contact daily 0.75 2023-08-17 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Contact https://compcylab.squarespace.com/join-us daily 0.75 2025-09-27 https://compcylab.squarespace.com/teaching daily 0.75 2026-01-26 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/383f5ce6-fc2c-4b0f-a731-88cbd3a720cf/bcb726.png Teaching - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/dd4d422c-177e-491c-be88-d57dd53de11d/comp683-20252.jpg Teaching - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1635780658043-2HY62XH8EN11MJS0DCAZ/class_pic.png Teaching - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://compcylab.squarespace.com/people daily 0.75 2026-04-07 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1613242097559-RVMNI6DY9RTZSHLADTRS/IMG_3053.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1629984289262-H2VJF5L5WFTMC53SP9NC/IMG_2944.JPG People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1652214515273-UDK0U9GM2Z4EJSZL7VVX/outdoorsy_headshot.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1627923901063-NC4MJUE44Z1UK8YBE2MD/photo_ranekj.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1613246242972-2FGJXQFJDBA3LS3GY9RU/haidong_yi.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1645125849509-W8NKT9AHER7OG1SVHVTN/headshot_cads.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/43986669-6959-4215-92f2-dd21fcfa01a0/F-cYk-uW0AATduB.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/9e1aa69b-376e-41ad-acff-1485e249756c/IMG_4172.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/7ef0f61a-5be7-4c4b-a5cb-f9188a763820/lab_picture.jpeg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/de0b4055-e5a2-4b69-ab29-7a7906db0982/NS_headshot_2026.jpg People https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/7fd3909b-8bfd-4693-a7ef-468c8a014abc/me_math_dept.jpg People https://compcylab.squarespace.com/new daily 0.75 2025-06-16 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/fe0f9a68-3285-49f6-a7de-d50b5ad5e8eb/Screen+Shot+2024-05-14+at+9.42.57+AM.png News and Photos Congratulations to Haidong and Sneha who graduated on Saturday May 12. Haidong completed his PhD and Sneha completed her BS. We have been so grateful to have them in the lab for the past few years. Haidong was the first member of the lab and notably developed CytoSet, which is a set-based encoding strategy for featurizing multi-sample single-cell datasets. We have been able to readily use CytoSet across a range of single-cell datasets where we to predict an outcome from the entire immune landscape. Haidong’s commitment to writing good software and to setting up important pipelines in the lab has been invaluable. Thank you Haidong for all of your hard work and creativity! Sneha finished her BS in computer science and minored in neuroscience. She also earned highest honors in computer science, based on her work in studying age-related changes in the microglia transcriptome. Sneha’s bold curiosity has been quite impressive, and it was an absolute joy to work with her. https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/e8d9ae29-059b-4236-aa6b-4242a2fcfa0a/IMG_1111.jpg News and Photos - Thanks to all the amazing students in the lab / collaborators for a productive and fun semester and year! Here are some highlights of new papers and proposals. DELVE. Jolene’s method DELVE for trajectory-preserving feature selection was published in nature communications. We are already using this in many projects with dynamic or temporal single-cell data to identify modules of features with related dynamic patterns. Differential Abundance Benchmarking. Haidong’s differential abundance benchmarking study was published in Genome Biology. This paper systematically explores how to choose the appropriate differential abundance method for a given single-cell dataset to most readily identify condition-specific prototypical cells. Funding. We got an R21 funded in collaboration with Todd Cohen to develop new methods for identifying meaningful spatial configurations of cell-types and pathologies in the brain that correlate with the aging and neurodegeneration process, as assayed through imaging mass cytometry. Very excited to continue to develop the neuroimmune focus in the lab. New Student. We are very excited to welcome a new BCB student to the lab, Luvna Dhawka. Luvna has a very interesting background in neuroscience and computational biology and will use these expertise to study sex differences in the microglia transcriptome in aging and neurodegeneration. Welcome Luvna! Very proud of all of our students for all of the hard work this semester!! https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/f9701c07-fa4f-4cd0-94eb-f66e11453d66/IMG_5832.jpg News and Photos - 2023 was a great year! Thanks to our great students, collaborators, and colleagues for another great year. This was a great year of starting to work more in neuroimmunology, graduating our first PhD student, and starting new collaborations at UNC. Here is a photo from a recent lab dinner as osteria georgi (highly recommend. I am not really a pasta person, but this was impressive). https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/ee37638a-3b88-46e9-a543-6d93c5d7917a/image000000.jpg News and Photos Photo from the doctoral hooding ceremony in May, 2023. https://compcylab.squarespace.com/comp790166-computational-biology-sp2022 daily 0.75 2021-12-20 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1640026218813-D68O7J1I9AQ6HULKN0AF/class_pic.png Comp790-166: Computational Biology Sp2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://compcylab.squarespace.com/software daily 0.75 2026-06-04 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1650396083721-AB3PWP2OSO9E7ETN2BOH/cytoSet.jpg Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1650397158313-QFBG1TSPN8UKDLBGTUYF/Screen%2BShot%2B2022-04-19%2Bat%2B3.38.39%2BPM.jpg Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1650399412313-LCM7V0J45I41M0A0R5Y4/Screen%252BShot%252B2022-04-19%252Bat%252B4.13.35%252BPM.jpg Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1650399563852-JFIO4NJVGBSK4VN2V0QQ/Screen%2BShot%2B2022-04-19%2Bat%2B3.59.47%2BPM.jpg Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1650400171818-YB4HHR428LHT8N4F77LE/Screen%25252BShot%25252B2022-04-19%25252Bat%25252B3.24.51%25252BPM.jpg Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1657308446593-PL91ESWD3CIP7JWIC9HF/Screen%2BShot%2B2022-07-08%2Bat%2B3.26.35%2BPM.jpg Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/ccb7268b-4697-4360-a85c-23af0393bb2e/Screen+Shot+2022-10-24+at+11.50.41+AM.png Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/dbdf35c7-5eb5-4503-bcc0-ed05dedd81f2/pipeline.png Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/27320fc8-49ad-42a8-8014-b14122881165/microglia_img.png Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/4be216d6-a7c8-457e-8cc1-ef25c76b4b85/Screen+Shot+2025-10-23+at+6.17.03+PM.png Software https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/381a27fe-25ae-4d43-a3a7-43bff88052cc/MICRON_marketing+%281%29.png Software https://compcylab.squarespace.com/5-key-papers daily 0.75 2025-10-30 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/6a866fb0-dea1-4b89-90af-efade25b2af8/Screen+Shot+2025-10-29+at+6.53.19+PM.png https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1650396083721-AB3PWP2OSO9E7ETN2BOH/cytoSet.jpg https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/27320fc8-49ad-42a8-8014-b14122881165/microglia_img.png https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1657308446593-PL91ESWD3CIP7JWIC9HF/Screen%2BShot%2B2022-07-08%2Bat%2B3.26.35%2BPM.jpg https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/dbdf35c7-5eb5-4503-bcc0-ed05dedd81f2/pipeline.png https://compcylab.squarespace.com/about daily 1.0 2025-10-23 https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1613243871541-UALU7X8FVMUU50VN7BU0/Screen+Shot+2021-02-10+at+12.29.49+PM.png Research https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/4190fa29-4abc-42c5-ab37-3277a15559ec/overview_featurization+%281%29.png Research Featuizing and Creating Summaries of the Immune Sytem : We develop methods to encode the rich information about the immune system collected through modern high-throughput immune-profiling techniques, such as CyTOF and imaging CyTOF into a compact, mathematical abstraction. Such abstractions can be used in downstream clinical prediction tasks. https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1620756418366-8QLL1ZHGVT8LGW4HCLHH/Screen+Shot+2021-05-11+at+2.04.44+PM.png Research - Make it stand out Metaclustering Approach for Automated Cell Population Discovery Across Multiple Samples. from Stanley et al. Nature Communications. 2020. [Paper] https://images.squarespace-cdn.com/content/v1/60240a133367ac2982ab7aee/1620756942638-0SQDSPQ4L4J5SXVLV0GL/Screen+Shot+2021-05-11+at+2.15.12+PM.png Research - Make it stand out Set Modeling Meets Flow and Mass Cytometry. from Haidong Yi and Natalie Stanley. Proceedings of ACM-BCB 2021. [Paper on BioArXiv] [Published Paper]